Lifehacker
Tips to hack your life.

Penny-Arcade
Two gamers rule the world.

Steve Pavlina's Personal Development Blog
Self-help for smart people.

TechCrunch
Another silicon Valley Web 2.0 blog, TechCrunch is great. They review new Web 2.0 ventures, which is good, because there are a lot of them.

BlogYourMind (Italian)
This blog is indeed all in Italian. I have been trying to read it for years.